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6-Letter Words Starting with OP

For puzzles requiring OP prefixes, here are all 6-letter word options. Popular examples include OPAQUE, OPENED, OPENER, plus OPENLY, OPERAS, OPERON and many more. Click any word for its full definition and usage.

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21 words
Word Definition Length Syllables
opaque62
opened63
opener63
openly63
operas63
operon63
ophite62
opiate62
opined63
opines63
opioid62
opiums62
oppose62
oppugn62
opsins62
optics62
optima63
optime62
opting62
option62
opuses63

FAQs

Are OP-starting words common?
OP is a frequent start; probing vowel swaps after OP quickly narrows options.

Is this list good for crosswords?
Yes—filter by length mentally and scan definitions when available.